Systems Biology as defined in this article is the analysis of the relationships among the elements in a system in response to genetic or environmental perturbations with the goal of understanding the system or the emergent properties of the system. A system can be protein molecules carrying out a simple task or it can be a complex set of proteins working together to achieve a much more complex task. Therefore these systems include molecules, cells, organs, individuals, and even entire ecosystems. The emergence of this field brings forth new sets of challenges that we are facing today in the world of healthcare. Understanding these systems to the fullest will help us in creating a more efficient way to diagnose and treat patients, which is exactly what pharmacogenetics is aimed at. Medical efficiency has been one of the hottest topics of debate recently. Efficiency can be in a number of different things including the treatment of the patients, the time to diagnose, and the accuracy of diagnosis. This articles main point is that understand systems biology and proteomics is the key to making medicine more predictive and preventative. Proteomics, the large scale study of proteins, has increased significantly within the last five years according to the article. I found this interesting because the article also states that cell behavior cannot be studied simply by looking at genes and mRNAs that encode them, which is why protoeomics was established. This article was enlightening as it taught me a lot more than I knew about the current state of personalized medicine, but I would have liked to see more technical examples about how this research can pinpoint certain diseases because this article mainly focused on the abstract.
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